Donation treatment

Egg donation

A small proportion of treated women have little or no chance of getting pregnant with their ova.

Treatment of infertility with the help of donated eggs is necessary and suitable, especially for women who have experienced no production of their egg (absence or premature ovarian failure) or with insufficient egg quality. These conditions often occur due to genetic reasons, after surgical removal of both ovaries, oncological treatment, or unknown reasons.

Such couples are offered treatment with ova retrieved from a healthy voluntary donor. Treatment with donated ova is demanding in terms of organization, requiring good cooperation between the infertile couple and the donor with the physician and the embryology team.

Egg donor selection

Candidates for voluntary egg donation go through a demanding selection process to ensure the highest possible success of treatment and optimal health of children conceived in this way. The donor can be a fertile woman between the ages of 18 and 34 who successfully undergoes the required examinations during the selection process.

Egg donor examination

• Examination for some sexually transmitted diseases: syphilis, infectious hepatitis B and C and HIV (negative finding required)
• Examination of blood group and Rh factor
• Examination of sex hormones (the result must correspond to a fertile woman)
• Gynecological examination including ultrasonography
• Karyotype examination (normal female karyotype required)
• Examination of gene mutations for selected autosomal recessive diseases
• Clinical-genetic consultation (geneticist’s consent to reproductive cell donation is required)
• Pre-operative examination by a general practitioner or internist (good health is required to undergo egg retrieval)

In addition, the donor’s examination evaluates her data on transmissible and/or hereditary diseases, lifestyle, and other factors that could affect the health of the conceived child or recipient. If any of this is endangered, the candidate is excluded from the selection.

The course of treatment with donated eggs

Treatment with donated ova can be performed via harmonizing the donor and recipient cycle, or without harmonization of the donor and recipient cycle.

• WITH HARMONIZATION OF THE DONOR AND RECIPIENT CYCLE

Harmonization of the donor and recipient cycle is a very demanding treatment procedure in terms of organization. After potential suppression of the recipient’s pituitary ovarian activity, her uterus is prepared with the help of estrogens in such a way that her endometrium has the optimal thickness at the time of egg retrieval. On the day of retrieval, it is essential to have fresh or cryopreserved sperm of the recipient’s partner available. The recipient is then administered other medications to induce the maturation of the endometrium, which then occurs synchronously with the embryo cultivation. The result of the process is the transfer of fresh embryos into the recipient’s uterus. At the moment of transfer, the recipient’s endometrium should have an optimal thickness and maturity.

The advantage of this procedure is the reduction of losses resulting from cryopreservation of embryos or reproductive cells.

The disadvantage is that the degree of uncertainty in the preparation of the donor and the recipient multiplies.

• WITHOUT HARMONIZATION OF THE DONOR AND RECIPIENT CYCLE

Ova retrieved from the donor, or ova from a cryobank, are fertilized by the spermatozoa of the recipient’s spouse/partner. The fertilized embryos are then cryopreserved (frozen). The embryos are then thawed when the recipient is optimally prepared for embryo transfer.

The advantage is a simpler procedure in terms of organization, increasing the probability of a smooth course of treatment, especially in recipients with time-consuming employment or a long commute to our clinic.

The disadvantage is the small risk of loss of reproductive cells or embryos during cryopreservation.

Treatment success

The success rate of conceiving a child with this treatment method is 40% per performed cycle. With three treatment cycles, the cumulative success rate is around 70-80%.

Clinic guarantee

All our donors meet strict criteria pursuant to Czech and European legislation and the recommendations of the American Society for Reproductive Medicine (ASRM).

We guarantee complete mutual anonymity between the donor on the one hand and a recipient couple and children born after the treatment with donated reproductive cells on the other.

The clinic guarantees the performance of embryo transfer if a very serious male factor is not present.

The treatment price includes fertilization of 6 donor eggs.

Treatment with donated sperms

In male infertility, modern reproductive medicine can use advanced medical procedures (ICSI, surgical, and micromanipulation techniques) to help most couples have their own children.

However, a small proportion of treated men have little or no chance of having their own in a biological way. The cause is usually the complete absence of sperm production or sperm production of insufficient quality. Genetic causes or conditions after oncological treatment are common, but a significant part of the causes of sperm production disorders is unexplained.

A geneticist may exceptionally recommend even men with a normal spermiogram for treatment with donated sperm.

Such couples are offered treatment with sperm obtained from a healthy donor.

Sperm donation

Donor sperm can be used for intrauterine insemination (IUI-AID) or in vitro fertilization (IVF/ET).

Sperm donor selection

Sperm donor candidates go through a demanding selection process to ensure the highest possible success of treatment and optimal health of children conceived in this way. A donor can be a fertile man between the ages of 18 and 34 who, during the selection process, successfully undergoes the required examinations.

Sperm donor examination

• Repeated examination for some sexually transmitted diseases: syphilis, infectious hepatitis B and C and HIV (negative finding required)
• Examination of blood group and Rh factor
• Examination of urinary chlamydia (negative finding required)
• Spermiogram examination (perfect result required)
• Karyotype examination (normal male karyotype required)
• Examination of gene mutations for selected autosomal recessive diseases
• Clinical-genetic consultation (geneticist’s consent to reproductive cell donation is required)

Furthermore, during the donor's examination, his data on transmissible or hereditary diseases, lifestyle, and other factors that could affect the health of the conceived child or the recipient are evaluated. If any of this is endangered, the candidate is excluded from the selection.

Embryo donation

Infertility treatment using donated embryos (popularly also called “embryo adoption”) is necessary if both partners demonstrate a combination of serious infertility factors or genetic causes. Embryos intended for donation are created by in vitro fertilization of ova obtained from a healthy female donor and sperm from a healthy male donor.

Egg and sperm donors

The sperm must come from a man who meets all the selection criteria for an anonymous healthy donor, and similarly, the ova must be retrieved from a woman who meets all the selection criteria for an anonymous healthy donor. The combination of biological traits (height, physique, the color of eyes, hair, skin, blood type, Rh factors) of this female and male donor must correspond to the biological traits of the recipient couple.

Treatment with donated embryos

After the provision of appropriate donated ova and sperm cells, in vitro fertilization and cultivation of the resulting embryos are performed. When the recipient is ready, the embryos are inserted into her uterus. If it is not operationally possible to harmonize the preparation of the embryo and the recipient, the embryos are frozen and inserted into the recipient’s uterus when it is optimally prepared.